The History of Aspirin

aspirin

In the mid 1900s, the pain killer of choice was plain aspirin AKA acetylsalicylic acid. Today, there is a host of pain killing choices. These depend upon the nature of the pain as well as the health issues of the patient. How does the laboratory relate to aspirin history?

It was First

Although during the 1950s and 1960s, other painkillers (most notably acetaminophen and ibuprofen) made a dramatic entrance into the pain killer market, aspirin was first. Here is the story.

From ancient times, it was known the bark of the willow tree (rich in salicylates) possessed special properties. A tea made from this bark was useful in fighting fever. It also aided in reducing inflammation and pain. Simple salicylic acid has the structural formula,
(HO-C₆H₄-COOH)

aspirinAspirin History: the Laboratory

In 1853, chemist C.F. Gerhardt first prepared acetyl salicylic acid by combining acetyl chloride and sodium salicylate. The overall reaction is:

CH₃COCl + HO-C₆H₄-COO⁻Na⁺ → NaCl + CH₃COO-C₆H₄-COOH

aspirinChemist Felix Hoffmann, employed by Bayer, a company that once specialized in dyes, is generally credited with producing a stable form of acetyl salicylic acid in 1897. It was first marketed as Aspirin®, a company, rather than a chemical name.

Making a Comeback

Although other pain killers began stripping away much of the market, acetyl salicylic acid later earned a reputation as a blood thinner, well suited in preventing certain kinds of heart attacks. The renewed interest in aspirin enabled the company, founded in 1863, to continue to prosper 150 years later. Sometimes simpler is better.

It remains to be seen even now what further, future, applications there will be for the simple substance acetyl salicylic acid.

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