It was FirstAlthough during the 1950s and 1960s, other painkillers (most notably acetaminophen and ibuprofen) made a dramatic entrance into the pain killer market, aspirin was first. Here is the story.
From ancient times, it was known the bark of the willow tree (rich in salicylates) possessed special properties. A tea made from this bark was useful in fighting fever. It also aided in reducing inflammation and pain. Simple salicylic acid has the structural formula, (HO-C₆H₄-COOH)
Aspirin History: the LaboratoryIn 1853, chemist C.F. Gerhardt first prepared acetyl salicylic acid by combining acetyl chloride and sodium salicylate. The overall reaction is:
CH₃COCl + HO-C₆H₄-COO⁻Na⁺ → NaCl + CH₃COO-C₆H₄-COOHChemist Felix Hoffmann, employed by Bayer, a company that once specialized in dyes, is generally credited with producing a stable form of acetyl salicylic acid in 1897. It was first marketed as Aspirin®, a company, rather than a chemical name.
Making a ComebackAlthough other pain killers began stripping away much of the market, acetyl salicylic acid later earned a reputation as a blood thinner, well suited in preventing certain kinds of heart attacks. The renewed interest in aspirin enabled the company, founded in 1863, to continue to prosper 150 years later. Sometimes simpler is better.
It remains to be seen even now what further, future, applications there will be for the simple substance acetyl salicylic acid.
- Bayer Aspirin: Homepage
- American Heart Association: What are Anticoagulants and Antiplatelet Agents?