Organic Chemistry: What is a Lactam?

Chemistry
Most have never heard of a lactam. What is it? How can it be produced? Compounds are chemicals formed by combining two or more different atoms, the basic building blocks of matter. Organic compounds contain carbon, frequently bonded to itself, whether in chains, rings, or some other geometric structure. There are so many organic compounds, they must be categorized according to "functional groups." Functional groups are specialized structures within a compound that may contain a special atom, such as nitrogen, sulfur, phosphorous, etc. One kind of compound categorized by functional group is an amide. An amide results when an organic acid group reacts with a nitrogen-containing amine group and loses water. A lactam is a special kind of amide. It may serve as an intermediate in forming heterocyclic rings. Inorganic…
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Forming Nitrogen Heterocycles from Aliphatic Amino Acids

Chemistry
How are nitrogen heterocycles formed from aromatic amines? Aliphatic hydrocarbons¹ take a number of forms. The simplest is written CH₃(CH₂)nCH₃, where n is a positive integer.²  Replace a hydrogen atom at one end of the chain with a carboxylic acid group (-COOH) and a hydrogen atom at the other end with an amino group (-NH₂), and you have a straight chain amino acid. For instance, choose n = 3. That gives the molecule HOOC-CH₂-CH₂-CH₂-CH₂-NH₂ Its name is 5-aminopentanoic acid or 5-aminovaleric acid. Cyclization Under the right conditions, this species can be cyclized to form an amine salt. The salt is then converted to a cyclic amide, a delta lactam. The lactam is next reduced to the amine piperidine. The overall process is illustrated in Fig. 1. Nitrogen Heterocycles A cyclic…
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